RESEARCH SERVICES

The Human Genome is composed of 3 billion nucleotides carrying hereditary information which determines an individual´s genetic potential. There is about 0.1% - 0.2% genomic DNA sequence difference between races and individuals, due mainly to single nucleotide polymorphisms (SNPs). Many of the SNPs can generate different inherited biochemical characteristics. For example, the ABO blood group site markers, leukocyte HLA site markers and individual disparities in drug metabolism. Knowledge of the DNA sequence differences and single nucleotide polymorphisms and their significance has begun to revolutionize diagnosis, treatment, prognosis and prevention.
 

Genomic DNA gains and losses can play a causal role in many diseases. Comparative genomic hybridization (CGH) is a powerful technique for the detection of chromosomal imbalances. CGH can also be used to identify different genes in diverse subtypes of the same species, thus indirectly confirming those phenotypes. The CGH method is based on a comparison of the test and control DNA samples which are labeled with different fluorophores, equally mixed, and simultaneously hybridized on one microarray, which can measure the DNA copy number differences between the test and control samples rapidly .
 

Description
CapitalBio´s Expression Profiling Array Services guarantee the quality of your results. The exceptional quality of our services were highlighted in the recent FDA-sponsored MicroArray Quality Control (MAQC) project (Nature Biotechnology,24(9): 1140-1150, 2006). CapitalBio’s highly trained specialists manufacture, hybridize, scan, and conduct a preliminary analysis of your arrays. There is no need for you to train your lab personnel in highly specialized techniques or purchase expensive instruments to fabricate arrays in-house. Moreover, because CapitalBio´s products range from ready-to-use arrays to customizable array designs, you will be able to explore the complex bio-world and answer your research questions more quickly and cost effectively.

Transcription factors (TF) regulate gene transcription through DNA-protein interactions, such as direct binding with DNA. In order to mediate a specific gene transcription, TFs bind in a sequence-specific manner to certain promoter sequences that are usually located upstream from its target gene. By combining chromatin immunoprecipitation using TF specific antibodies, also known as the ChIP assay, then labeling IP-captured promoter-DNA as a probe for hybridization with an array that is pre-spotted with various promoter sequences, it is possible to determine many genetic targets for a given TF. The first generation technology called "ChIP-on-chip" has demonstrated its effectiveness (Ren, B. et al., (2000) Science 290:2306-2309).
 

CapitalBio´s Expression Profiling Array Services guarantee the quality of your results. The exceptional quality of our services were highlighted in the recent FDA-sponsored MicroArray Quality Control (MAQC) project (Nature Biotechnology, 24(9): 1140-1150, 2006). CapitalBio’s highly trained specialists manufacture, hybridize, scan, and conduct a preliminary analysis of your arrays. There is no need for you to train your lab personnel in highly specialized techniques or purchase expensive instruments to fabricate arrays in-house. Moreover, because CapitalBio´s products range from ready-to-use arrays to customizable array designs, you will be able to explore the complex bio-world and answer your research questions more quickly and cost effectively.